Interleukin-1beta gene polymorphism in Taiwanese
patients with gout.
Title: Interleukin-1beta gene polymorphism in
Taiwanese patients with gout.
Author: Chen ML
Publication: Rheumatol Int. 2005 Apr;25(3):179-82.
Epub 2003 Dec 6.
In this study, the authors wanted to see whether polymorphism
(or different forms) of interleukin-1 betal (IL-1beta) promoter
and exon 5 gene can serve as a genetic “marker” of
gout.
The authors enrolled 196 subjects with gout and 103 healthy control
subjects and examined their DNA. They found that there was no
association of the IL-1beta promoter region with gout –
however, they found that there is some link between this promoter
region with hypertriglyceridemia (increased levels of triglycerides
in the blood).
