Apolipoprotein Polymorphism in Hyperlipidemia and Gout

Title: Contribution of polymorphism in the apolipoprotein AI-CIII-AIV cluster to hyperlipidaemia in patients with gout.
Cardona et al.
Publication: Ann Rheum Dis. 2005 Jan;64(1):85-8. Epub 2004 Apr 28.

Studies have shown that hyperuricaemia or high levels of uric acid in the blood serum is related to insulin resistance syndrome, and that apolipoprotein AI-CIII-AIV gene cluster is linked to insulin resistance. The author wanted to see whether there is any linkage between polymorphism (different forms) of the apolipoprotein AI-CIII-AIV gene and gout as well as lipid levels.

The authors enrolled 68 subjects with gout and 165 healthy subjects and measured their plasma cholesterol, trigelycerides, uric acid, triglyceride, and so forth.

After examining which form of apolipoprotein AI-CIII-AIV these subjects had, the authors noticed that a particular form of apolipoprotein (denoted A allele at position -75 bp) was found more frequently in patients with gout. These patients also had higher levels of cholesterol, triglycerides, uric acid, basal glycaemia (glucose level), and HDL cholesterol. The absence of this particular form of apolipoprotein was linked to increased plasma triglyceride levels.

The authors concluded that this form of apolipoprotein could lead to changes in the levels of lipoproteins, which can lead to gout.

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