Management of Gout and Hyperuricemia

Title: Recent advances in the management of gout and hyperuricemia
Wortmann RL
Publication: Curr Opin Rheumatol. 2005 May;17(3):319-24.

Selective COX II inhibitors have been found to be effective for active gout. In this article, the author reviewed two potential drugs currently in clinical trials: febuxostat, an inhibitor of the xanthine oxidase enzyme (which is involved in uric acid production), and PEGylated uricases (a chemically modified recombinant mammalian enzyme that degrades uric acid).

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