Management of Gout and Hyperuricemia
Title: Recent advances in the management of
gout and hyperuricemia
Author: Wortmann RL
Publication: Curr Opin Rheumatol. 2005 May;17(3):319-24.
Selective COX II inhibitors have been found to be effective for
active gout. In this article, the author reviewed two potential
drugs currently in clinical trials: febuxostat, an inhibitor of
the xanthine oxidase enzyme (which is involved in uric acid production),
and PEGylated uricases (a chemically modified recombinant mammalian
enzyme that degrades uric acid).