Acne Fulminans in SAPHO Syndrome

Title: Acne fulminans with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome treated with infliximab
IQbal M, Kolodney MS
Publication: J Am Acad Dermatol. 2005 May;52(5 Suppl 1):S118-20.

Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome can cause severe and scarring acne breakouts in the back, chest and face called acne fulminans. The authors descrive a treatment of a patient with infliximab, a new monoclonal antibody against tumor necrosis factor-alpha. They described that after 10 months, the severe lesions were reduced by 70%, and suggest that infliximab may be a treatment option for acne fulminans that do not respond to other treatments.

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