Brain Imaging in Acne Patients Treated with Isotretinoin

Title: Functional brain imaging alterations in acne patients treated with isotretinoin
Bremner JD, et al.
Publication: Am J Psychiatry. 2005 May;162(5):983-91.

To pursue the possible link between isotretinoin and depression, the authors measured the brain functioning in adults using positron emission tomography (PET) scan, before and 4 months after isotretinoin or antibiotic treatments. They found that patients treated with isotretinoin have decreased brain metabolism in the orbitofrontal cortext, an area of the brain known to mediate the symptoms of depression. The patients treated with antibiotics have no such change in brain function. However, there is no difference in the severity of depression between the patients who were given isotretinoin and antibiotic treatment.

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