RALGA (Diacneal)and postinflammatory hyperpigmentation
Title: RALGA (Diacneal), a retinaldehyde and
glycolic acid association and postinflammatory hyperpigmentation
in acne – a review
Author : Katsambas AD
Publication : Dermatology. 2005;210 Suppl 1:39-45.
After the acne went away, some people have postinflammatory hyperpigmentation
(PIH) or red spots. The author note that retinaldehyde (RAL) a
precursor to retinoic acid has a depigmenting activity; and that
glycolic acid (GAL) can also decrease the amount of pigment (actually
by wounding the skin and causing it to repair itself).
The authors reviewed preclinical and clinical trials that showed
the combination of RAL 0.1% and GAL 6% in a drug called RALGA
(Diacneal) is effective and safe in treating post-acne pigmentations.