Retinaldehyde and Glycolic Acid for Acne

Title: Topical retinaldehyde with glycolic acid: study of tolerance and acceptability in association with anti-acne treatments in 1,709 patients.
Dreno B, et al.
Publication: Dermatology. 2005;210 Suppl 1:22-9.

Retinaldehyde (RAL) is a chemical intermediate in the conversion process of vitamin A to retinoic acid. It has been shown to play a role in the formation and growth of keratinocytes or skin cells that produce keratin. These keratinocytes play a significant role in the formation of acne lesions.

Glycolic acid can increase the exfoliation of the skin, specifically the corneocytes or the dead, keratin-filled flat, thin cells of the outer layer of the skin.

The authors wanted to test the tolerance and effectiveness of the combination RAL and glycolic acid in a commercial product Diacneal in treating acne patients. They enrolled 1,709 acne patients in this 90-day study.

The authors reported that by the patients had significant decrease in acne lesions, without significant side effects.

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