RU 58841-myristate Prodrug for Acne
Title: RU 58841-myristate – prodrug development
for topical treatment of acne and androgenetic alopecia
Authors: Munster U, eta l.
Publication: Pharmazie. 2005 Jan;60(1):8-12.
Acne and androgenetic alopecia (male pattern baldness) are linked
to the effects of androgen or male sex hormones, and therefore
should be alleviated by the use of anti-androgen chemicals.
In this paper, the authors present a new anti-androgen chemical
for topical therapy called RU 58841-myristate (RUM), developed
from a cultured mouse cell line. In various human skin cell lines,
RUM is rapidly metabolized into RU 58841, a potent anti-androgen.
In order to improve targeting only selected tissues, the authors
loaded RUM into solid lipid nanoparticles (SLN), basically encapsulating
it inside a skin-permeating spheres. The authors then tested the
ability of the RUM loaded SLN to permeate pig’s skin (as
a testing substitute for human skin) and to its ability to adhere
onto hair follicles (both human and pig in origin) by using an
electron microscope.
The authors concluded that RUM loaded SLN should be considered
as topical anti-androgen therapy for acne and male pattern baldness.
