Superoxide Dismutase and Myeloperoxidase Activities in Acne

Title: Superoxide dismutase and myeloperoxidase activities in the polymorphonuclear leukocytes in acne vulgaris
Kurutas EB, Arican O, Sasmaz S.
Publication: Acta Dermatovenerol Alp Panonica Adriat. 2005 Jun;14(2):39-42.

In this study, the authors wanted to investigate the role of oxygen radicals in acne inflammation. They enrolled 43 patients with acne and 24 healthy controls, and measured enzyme activities (myeloperoxidase/MPO and superoxide dismutase/SOD) to check the levels of oxygen radicals.

The authors found that there is no difference in the activity of MPO, but a statistically lower activity of SOD in patients with acne as compared to the healthy control. Because of this, the authors suggest that oxygen radicals may play a role in acne and that new anti-acne drugs should include substances with anti-oxidant properties.

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