NF-kB and Activator Protein-1 in Acne

Title: Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acne lesions in vivo.
Authors:
Kang S, et al.
Publication: Am J Pathol. 2005 Jun;166(6):1691-9.

The authors found that certain cellular components, classified as transcription factors called nuclear factor-kappaB and activator protein-1 are activated in acne lesion. These transcription factors then cause increased activity of inflammatory cytokines and matrix-degrading metalloproteinases, which cause inflammation and collagen degradation, respectively.

The authors suggest that these transcription factors can be target of drug development for treatment of severe acne.







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