Vitamin E and Isotretinoin Side Effects for Acne

Title: Vitamin E does not reduce the side-effects of isotretinoin in the treatment of acne vulgaris
Kus S, et al.
Publication: Int J Dermatol. 2005 Mar;44(3):248-51.

The side-effects of isotretinoin is dry skin as well as increased lipid (cholesterol and triglycerides) and liver enzymes levels. Since vitamin E has been shown to decrease the toxicity of some high-dose retinoids, the authors conducted an experiment whether vitamin E would reduce isotretinoin’s side effects.

In this test, 82 patients were treated either with 1 mg/kg/day isotretinoin alone or combined with 800 IU vitamin E per day. After 15 weeks, side effects such as dry skin, redness, inflammation of the lips, and lipid and liver enzyme levels were checked. The result? No difference in frequency and severity of these side effects between the two groups.

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