Zinc Gluconate on Erythromycin-Resistant Acne

Title: Effect of zinc gluconate on propionibacterium acnes resistance to erythromycin in patients with inflammatory acne: in vitro and in vivo study.
Dreno B., et al.
Publication: Eur J Dermatol. 2005 May-Jun;15(3):152-5.

The authors noted that antibiotics, especially erythromycin, have had declining effectiveness in treating acne. This is due to the increased resistance to the drugs by the acne-causing bacteria, Propioniium bacteria acnes.

Since zinc salts can also work in reducing inflammation and killing bacteria, the authors wanted to know whether there is a difference in its effectiveness against the drug-resistant strain of P. acnes.

The authors found that zinc can reduce the resistance of P. acnes to erythromycin in test tube environment, and can also reduce acne lesions after 2 months in patients suffering from acne. (These patients received 30 mg of zinc gluconate daily for 2 months).

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