Angiogenesis in Psoriasis and Psoriatic Arthritis

Title: Angiogenesis in psoriasis and psoriatic arthritis: clues to disease pathogenesis.
Authors: Leong TT, et al.
Publication: Curr Rheumatol Rep. 2005 Aug;7(4):325-9.

Psoriasis is a common chronic skin condition affecting 2% of the population, and is associated with inflammatory arthritis (psoriatic arthritis) in up to 40% of the cases.

Psoriatic arthritis patients account for 15% of patients coming in for inflammation of the synovial membrane (membranes in the joint cavities), therefore it represents the second most common category after rheumatoid arthritis.

There are a number of common characteristics that link the skin and joint inflammatory process. In both psoriasis and psoriatic arthritis, angiogenesis or formation of new blood vessels seems to be a fundamental inflammatory response early in the course of the disease development. Significant abnormalities of the morphology of blood vessels and growth factor for new blood vessels have been prescribed in both diseases.

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