ICAM-1 Antibody in Psorasis Mouse Model

Title: Efficacy of the fully human monoclonal antibody MOR102 (#5) against intercellular adhesion molecule 1 in the psoriasis-severe combined immunodeficient mouse model.
: Boehncke WH, et al.
Publication: Br J Dermatol. 2005 Oct;153(4):758-66.

Intercellular adhesion molecule 1 (ICAM-1) is involved in leukocyte or white blood cell adhesion, extravasation (forcing of blood or lymph from a blood or lymph vessel out into the surrounding tissue), and lymphocyte activation. Because of this, the authors suggested that targeting ICAM-1 might work as treatment for psoriasis.

The authors selected human monoclonal antibody MOR102(#5), which was shown to interfere with lymphocyte activation and adhesion in test tubes, as well as for its effectiveness against psoriasis in mouse (using psoriasis-severe combined immunodeficient mouse model).

The authors confirmed the ability of MOR102(#5) to inhibit lymphocyte adhesion to ICAM-5, and also found that MOR102(#5) reduced lymphocyte proliferation in cell cultures. When injected into psoriatic lesion grafted onto mice (at a dosage of 10 mg/kg, every other day for 4 days), the authors found:

  • Reduction in the epidermal thickness
  • Reconstitution of the keratin layer of the skin
  • Reduction in inflammation.

The authors suggested that the therapeutic activity of MOR102(#5) antibody might be due to targeting of ICAM-1 on skin cells that produce keratin and the prevention of T-cell activation. Based on this experiment, fully human monoclonal antibody MOR102(#5) should be clinically tested as treatment for psoriasis.

Editor’s Note: lymphocytes are cells formed in the lymphoid tissue, and are a component of white blood cells. These cells are involved in the body’s immune response.

Keratin is a tough, insoluble protein that is a major component of hair and nails.

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