Brauer Disease with Psoriasis
Title: Punctate palmoplantar keratoderma (Buschke-Fischer-Brauer
disease) with psoriasis: a rare association showing excellent
response to acitretin.
Authors: Al-Mutairi N, et al.
Publication: J Drugs Dermatol. 2005 Sep-Oct;4(5):627-34.
Buschke-Fischer-Brauer Disease or Hereditary punctuate palmoplantar
keratoderma is a rare skin disorder marked with formation of multiple
spots of excessive growth of horny or keratinous tissues in the
palms of the hand and soles of the feet.
The authors described a 49 year old male patient with this disease,
who also had many unusual characteristics such as late onset of
the disease in his fourth decade and changes in his nails:
- vertical stripes
- curved nails
- pits in the fingernails
- thickening of the nail
- subungual hyperkeratosis or formation of keratinous tissue
under the nail
- yellow discoloration of the toenails
The patient developed skin lesion typical of psoriasis 7 years
after the appearance of the keratinous growth. Previously, there
was no association between psoriasis and Buschke-Fischer-Brauer
Disease.
The patient’s skin lesion cleared completely within 3 months
with acitretin oral retinoid therapy.
