Brauer Disease with Psoriasis

Title: Punctate palmoplantar keratoderma (Buschke-Fischer-Brauer disease) with psoriasis: a rare association showing excellent response to acitretin.
Authors: Al-Mutairi N, et al.
Publication: J Drugs Dermatol. 2005 Sep-Oct;4(5):627-34.

Buschke-Fischer-Brauer Disease or Hereditary punctuate palmoplantar keratoderma is a rare skin disorder marked with formation of multiple spots of excessive growth of horny or keratinous tissues in the palms of the hand and soles of the feet.

The authors described a 49 year old male patient with this disease, who also had many unusual characteristics such as late onset of the disease in his fourth decade and changes in his nails:

  • vertical stripes
  • curved nails
  • pits in the fingernails
  • thickening of the nail
  • subungual hyperkeratosis or formation of keratinous tissue under the nail
  • yellow discoloration of the toenails

The patient developed skin lesion typical of psoriasis 7 years after the appearance of the keratinous growth. Previously, there was no association between psoriasis and Buschke-Fischer-Brauer Disease.

The patient’s skin lesion cleared completely within 3 months with acitretin oral retinoid therapy.

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