Clobetasol Lotion and Cream for Severe Psoriasis

Title: Clobetasol propionate lotion, an efficient and safe alternative to clobetasol propionate emollient cream in subjects with moderate to severe plaque-type psoriasis.
: Lowe N, et al.
Publication: J Dermatolog Treat. 2005 Aug;16(3):158-64.

Various formulations of the topical corticosteroid drug clobetasol propionate are currently used to treat psoriasis due to its anti-inflammatory, anti-pruritic (anti-itching), vasoconstrictive (ability to constrict blood vessels) and immunomodulating (ability to modulate the body’s immune response) properties.

The authors wanted to evaluate the efficacy, safety, and remission profile of clobetasol propionate lotion in comparison to that in form of emollient (softening) cream in patients with moderate to severe plaque-type psoriasis.

They enrolled 192 subjects in a multicenter, randomized study. These patients were divided into:

  • Clobetasol propionate lotion (82 patients)
  • Clobetasol propionate cream (81 patients)
  • Placebo (cream or lotion vehicle only) (29 patients)

After 4 weeks of treatment, the authors found that the results of clobetasol propionate lotion was better than placebo lotion, but was similar to that of clobetasol emollient cream. However, those who used clobetasol lotion had better remission profile 4 weeks after treatment than those who used the emollient cream form.

The authors concluded that the clobetasol propionate lotion is effective, safe, and well-tolerated alternative to the emollient cream form, with better remission profile after the treatment was completed.

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