Corneodesmosin in Caucasian, but not in Japanese
Psoriasis Cases
Title: Corneodesmosin (CDSN) gene association
with psoriasis vulgaris in Caucasian but not in Japanese populations.
Authors: Ameen M, et al.
Publication: Clin Exp Dermatol. 2005 Jul;30(4):414-8.
PSORS1 on chromosome 6, contains HLA-Cw6 allele or gene form
which encodes for a form of major histocompatibility immune system
protein, which is associated with susceptibility for psoriasis.
This genetic location also contains the corneodesmosin or CSDN
gene, which can also be responsible for susceptibility to psoriasis
based on its function in adhesion of keratinocyte cells or cells
that produce keratin.
The authors wanted to determine whether CSDN can be responsible
for psoriasis susceptibility by comparing British-Caucasian population
to Japanese-population.
The authors found that there was strong linkage of psoriasis
to both HLA-Cw6 and a particular allele or form of CDSN in Caucasian
population. However, there was no association to both HLA and
CDSN genes in Japanese population.
The authors suggested that this result supported a possible role
for CDSN in psoriasis in Caucasian population, and attributed
different genetic factors for psoriasis in the Japanese people.
