Corneodesmosin in Caucasian, but not in Japanese Psoriasis Cases

Title: Corneodesmosin (CDSN) gene association with psoriasis vulgaris in Caucasian but not in Japanese populations.
Authors: Ameen M, et al.
Publication: Clin Exp Dermatol. 2005 Jul;30(4):414-8.

PSORS1 on chromosome 6, contains HLA-Cw6 allele or gene form which encodes for a form of major histocompatibility immune system protein, which is associated with susceptibility for psoriasis. This genetic location also contains the corneodesmosin or CSDN gene, which can also be responsible for susceptibility to psoriasis based on its function in adhesion of keratinocyte cells or cells that produce keratin.

The authors wanted to determine whether CSDN can be responsible for psoriasis susceptibility by comparing British-Caucasian population to Japanese-population.

The authors found that there was strong linkage of psoriasis to both HLA-Cw6 and a particular allele or form of CDSN in Caucasian population. However, there was no association to both HLA and CDSN genes in Japanese population.

The authors suggested that this result supported a possible role for CDSN in psoriasis in Caucasian population, and attributed different genetic factors for psoriasis in the Japanese people.

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