New Corticosteroid Vehicle Formulations for Psoriasis

Title: Clinical studies of a new vehicle formulation for topical corticosteroids in the treatment of psoriasis.
Author: Stein L
Publication: J Am Acad Dermatol. 2005 Jul;53(1 Suppl 1):S39-49.

Topical corticosteroids are a common form of topical anti-inflammatory treatment of psoriasis. They are also available in different :

  • Treatment strength
  • Doses
  • Formulations
  • Vehicles (carrier base or solution for the drug) such as ointments, creams, and lotions.

Recently, mid-potency corticosteroid betamethasone valerate (BMV) and ultra-high-potency corticosteroid clobetasol propionate have become available.

The author reviewed the clinical studies on the efficacy and safety of these two corticosteroids, in forms of:

  • Betamethasone valerate 0.12% foam
  • Clobetasol propionate 0.05% foam

as treatments for scalp and non-scalp psoriasis.

The studies demonstrated that both topical agents are safe and effective treatments for scalp and non-scalp psoriasis. The foam vehicle forms of both corticosteroids are absorbed more rapidly and have greater total absorption when compared to the lotion or solution form. The foam vehicle form also appears to be associated with better patients’ compliance and improvement in their quality of life.

The authors concluded that due to the unique nature of the foam vehicle, combined with positive findings in lab settings, suggested that the new betamethasone valerate and clobetasol propionate foam formulations might expand the available treatment options for combination therapy.

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