Dobesilate for Plaque Psoriasis
Title: Dobesilate in the treatment of plaque
Authors: Cuevas P., Arrazola JM
Publication: Eur J Med Res. 2005 Sep 12;10(9):373-6.
Fibroblast growth factor (FGF)-mediated pathways are implicated
in the pathogenesis or disease development of psoriasis. The authors
proposed that targeting FGF signals might be useful in treatment
The authors reported a case study of treating a 43-year old man
with plaque psoriasis every day with dobesilate topical treatment.
Dobesilate is a FGF inhibitor. As early as day 14, the patients
had cleared or achieved improvement in psoriasis lesions.
The authors concluded that dobesilate offered a potential for
treatment of plaque psoriasis without any side effects associated
with topical corticosteroids.