Treatmetn of Psoriasis Flare Up after Efalizumab

Title: Psoriasis vulgaris flare during efalizumab therapy does not preclude future use: a case series.
: Lowes MA, et al.
Publication: BMC Dermatol. 2005 Aug 18;5:9.

The authors presented 2 patients with severe chronic plaque psoriasis who had been treated with numerous anti-psoriasis treatments with varied results. Initially, both responded well to treatment with efalizumab (anti-CD11 antibody, an immunesuppressant) but then experienced a flare of the disease after missing a dose.

After the disease had stabilized, both patients responded well to re-introduction of efalizumab. One patient required concurrent treatment with infliximab (an antibody against tumor necrosis alpha or TNF-alpha).

The authors concluded that efalizumab can still be administered after flare ups of psoriasis.

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