Psoriasis in Patients Treated with Interferon-Beta

Title: Activation of psoriasis in patients undergoing treatment with interferon-beta
: Navne JE, et al.
Publication: Ugeskr Laeger. 2005 Aug 8;167(32):2903-4.

Psoriasis is a chronic, inflammatory skin condition that is induced and aggravated by both internal body conditions and other external factors. Certain drugs have been associated with triggering psoriasis as side effects:

  • Lithium
  • beta blockers (medications for heart, high blood pressure and other conditions)
  • NSAIDs (non-steroidal anti-inflammatory drugs, such as aspirin or ibuprofen)
  • ACE inhibitors (drugs used to treat high blood pressure and heart failure)
  • anti-malarial drugs
  • interferon (glycoproteins produced by various cell types in an immune system response that can prevent viral replications)

The authors presented 2 patients with multiple sclerosis who had outbreaks of psoriasis when put on interferon-beta treatment. One patients had psoriasis at the injection site that last 6 years after the termination of the interferon treatement.

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