Interleukin-19 Associated with Psoriasis

Title: Interleukin-19 upregulates keratinocyte growth factor and is associated with psoriasis.
: Li HH, et al.
Publication: Br J Dermatol. 2005 Sep;153(3):591-5.

Interleukin (IL)-19 is a type of lymphokine that stimulates, regulates or modulates lymphocytes or white blood cells such as T cells. IL-19 signals through other proteins that have been shown to be involved in abnormal formation and proliferation of keratinocyte (cells that produce keratin).

The authors wanted to investigate the role of IL-19 in psoriasis. To do this, they measured the expression of keratinocyte growth factor (KGF) by polymerase chain reaction in cells treated with IL-19. They found that IL-19 can cause more KGF to be produced.

The authors then measured the level of IL-19 in the serum or blood of patients with psoriasis and healthy volunteers using antibodies against IL-19. They found that patients with psoriasis had statistically significant lower levels of IL-10 than healthy volunteer.

These results suggested that IL-19 played a role in the development of psoriasis.

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