Metalloproteinases in Psoriasis

Title: The role of metalloproteinases in psoriasis
: Flisiak I, et al.
Publication: Przegl Lek. 2005;62(2):119-22.

Metalloproteinases (enzymes containing metals that degrade proteins) play a crucial role in the:

  • destruction of tissue related to inflammation
  • carcinogenesis (formation of tumors)
  • wound healing
  • morphogenesis (formation of organs and parts of the body)
  • growth

In psoriasis, destruction of extracellular matrix proteins by metalloproteinases, following damage to the basement membrane can result in angiogenesis (formation of blood vessels) and infiltration of inflammation.

The activity of metalloproteinases can be controlled at different levels:

  • Genetic expression
  • Enzyme activation
  • Enzyme inhibition

In this paper, the author reviewed recently discovered role of metalloproteinases in the development of skin diseases, including psoriasis. They suggested development of compounds that inhibit metalloproteinases for treatment of psoriasis, and that measuring the levels of these enzymes can be useful for management and monitoring of the disease.

Editor’s Note: The extracellular matrix is a complex structure that surrounds and supports cells in a mammalian tissue.

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