Gene Expression in Peripheral Blood Mononuclear
Leukocyte in Psoriasis
Title: Gene expression profiling of peripheral
blood mononuclear leukocytes from psoriasis patients identifies
new immune regulatory molecules.
Authors: Koczan D, et al.
Publication: Eur J Dermatol. 2005 Jul-Aug;15(4):251-7.
The authors reported gene expression profile of peripheral blood
mononuclear cells (PBMC) from psoriasis patients who are currently
suffering from the disease versus those who are cured of it.
The authors identified 18 genes which showed differential expression
pattern, with the most significant differences for:
- Interleukin (IL)-8
- Annexin A3
- Cycloxygenase-2 (COX-2)
- Cell cycle regulator GOS2
- Pre-B cell enhancing factor (PBEF)
All of these genes are upregulated or expressed more in the diseased
Further analysis identified 3 pairs of genes:
- IL-8 and CDKN1C/p57
- Cyclooxygenase-2 and NR1D2
- Desmocollin-2 and CDKN1C/p57
that allowed accurate prediction of disease stages based on just
the gene expression patterns.
The authors concluded that the genes found in this differential
expression study might serve as potential targets for treatment