Gene Expression in Peripheral Blood Mononuclear Leukocyte in Psoriasis

Title: Gene expression profiling of peripheral blood mononuclear leukocytes from psoriasis patients identifies new immune regulatory molecules.
: Koczan D, et al.
Publication: Eur J Dermatol. 2005 Jul-Aug;15(4):251-7.

The authors reported gene expression profile of peripheral blood mononuclear cells (PBMC) from psoriasis patients who are currently suffering from the disease versus those who are cured of it.

The authors identified 18 genes which showed differential expression pattern, with the most significant differences for:

  • Interleukin (IL)-8
  • Annexin A3
  • Cycloxygenase-2 (COX-2)
  • Cell cycle regulator GOS2
  • Pre-B cell enhancing factor (PBEF)

All of these genes are upregulated or expressed more in the diseased stage.

Further analysis identified 3 pairs of genes:

  • IL-8 and CDKN1C/p57
  • Cyclooxygenase-2 and NR1D2
  • Desmocollin-2 and CDKN1C/p57

that allowed accurate prediction of disease stages based on just the gene expression patterns.

The authors concluded that the genes found in this differential expression study might serve as potential targets for treatment of psoriasis.

Main Menu
Health Articles
Health News
Health Research
Site Map

Health Conditions
Cardiovascular Health
Digestive Health
Infectous Diseases
Musculoskeletal Health
Pregnancy & Childbirth
Skin Health

Misc. Health Articles
Presidential Diseases

Medical Research

Psoriasis Overview
Psoriasis Pictures
Research Summaries

©copyright 2004 - Health In Plain English. All Rights Reserved.

Health Articles Health News Health Research Explained in Plain English