Pemphigus Foliaceus in Patient with Psoriasis
Title: A case of sporadic pemphigus foliaceus
in teenage girl with psoriasis vulgaris
Authors: Hasse-Cieslinska M, et al.
Publication: Pol Merkuriusz Lek. 2005 May;18(107):568-70.
The authors reported a case study of a 15-year old girl with
generalized redness of the skin, plaques with scales, vesicular
and erosive skin lesions. She was diagnosed as having pemphigus
foliaceus, and the symptoms occurred during the treatment for
psoriasis vulgaris.
The diagnosis was confirmed by histopathology and microscopy.
Blood tests revealed that a positive reaction against desmoglein
1 using a test using antibodies to detect a specific protein.
The patient was successfully treated by systemic corticosteroid
methylprednoisolone delivered intravenously and then by immunosuppressant
cyclophosphamide orally.
Editor’s Note: Pemphigus foliaceous is a skin
condition marked with blisters caused by aberrant immune reaction
where the body’s own antibody attack the skin cells. It
is marked by the presence of the antibody against desmoglein 1,
a protein “glue” that holds the skin together.
