Penicillin for Psoriasis

Title: Long-term use of penicillin for the treatment of chronic plaque psoriasis.
: Saxena VN, Dogra J
Publication: Eur J Dermatol. 2005 Sep-Oct;15(5):359-62.

Underlying streptococcal infection with no clinical manifestation might be responsible for chronic plaque psoriasis. In this 2-year open study, the authors investigated 30 patients with moderate to severe chronic plaque psoriasis. The majority of the patients (21 out of 30) had had this condition for 5 years or more and had been treated for psoriasis with no significant improvement and frequent recurrence.

The authors gave benzathine penicillin antibiotic 1.2 million units by intramuscular injection every two weeks. After 24 weeks, the dosage was reduced to 1.2 million units per month. The patients were assessed to detect side effects and observe the progress of the psoriasis at regular intervals.

The authors noted that after 12 weeks of treatment, the patients had improvement in PASI (Psoriasis Area and Severity Index) score. All patients showed excellent improvement at 2 years, with good tolerance to the therapy. The authors suggested a follow-up, controlled study to confirm the benefits of long-term use of benzathine penicillin in psoriasis treatment.

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