PSORS1C1 in Chinese Psoriasis Patients

Title: A study of PSORS1C1 gene polymorphisms in Chinese patients with psoriasis.
Authors: Chang YT, et al.
Publication: Br J Dermatol. 2005 Jul;153(1):90-6.

Genetic analyses have identified HLA-Cw*0602 as a gene form that is a major risk factor for chronic psoriasis in various ethnic groups.

There is another gene called the psoriasis susceptibility 1 candidate 1 (PSORS1C1) gene thought to be a potential genetic basis for psoriasis.

The authors wanted to see whether PSORS1C1 gene is linked to psoriasis in Chinese patients. To do this, they enrolled 143 Chinese patients with chronic plaque psoriasis and 188 healthy control subjects. They tested the DNA of these patients for HLA-Cw*0602 gene and mutations in the PSORS1C1 gene.

Although the authors found several mutations in the PSORS1C1 genes in Chinese patients with chronic psoriasis and healthy controls, there was no statistically significant link to psoriasis. On the other hand, there was a significant increase of the presence of HLA-Cw*0602 gene with early onset of psoriasis.

The authors concluded that PSORS1C1 gene might not play an important role in the development of psoriasis in Chinese patients.

Editor’s Note: HLA-C is a type of immune system protein found in the cell membrane, belonging to a class called MHC or Major Histocompatibility Complex Class I. This protein interacts with killer immunoglobulin-like receptors (KIR) on the surface of immune cells, specifically with natural killer (NK) cells and natural killer-T (NKT) cells.

Main Menu
Health Articles
Health News
Health Research
Site Map

Health Conditions
Cardiovascular Health
Digestive Health
Infectous Diseases
Musculoskeletal Health
Pregnancy & Childbirth
Skin Health

Misc. Health Articles
Presidential Diseases

Medical Research

Psoriasis Overview
Psoriasis Pictures
Research Summaries

©copyright 2004 - Health In Plain English. All Rights Reserved.

Health Articles Health News Health Research Explained in Plain English