PSORS1C1 in Chinese Psoriasis Patients
Title: A study of PSORS1C1 gene polymorphisms
in Chinese patients with psoriasis.
Authors: Chang YT, et al.
Publication: Br J Dermatol. 2005 Jul;153(1):90-6.
Genetic analyses have identified HLA-Cw*0602 as a gene form that
is a major risk factor for chronic psoriasis in various ethnic
groups.
There is another gene called the psoriasis susceptibility 1 candidate
1 (PSORS1C1) gene thought to be a potential genetic basis for
psoriasis.
The authors wanted to see whether PSORS1C1 gene is linked to
psoriasis in Chinese patients. To do this, they enrolled 143 Chinese
patients with chronic plaque psoriasis and 188 healthy control
subjects. They tested the DNA of these patients for HLA-Cw*0602
gene and mutations in the PSORS1C1 gene.
Although the authors found several mutations in the PSORS1C1
genes in Chinese patients with chronic psoriasis and healthy controls,
there was no statistically significant link to psoriasis. On the
other hand, there was a significant increase of the presence of
HLA-Cw*0602 gene with early onset of psoriasis.
The authors concluded that PSORS1C1 gene might not play an important
role in the development of psoriasis in Chinese patients.
Editor’s Note: HLA-C is a type of immune system
protein found in the cell membrane, belonging to a class called
MHC or Major Histocompatibility Complex Class I. This protein
interacts with killer immunoglobulin-like receptors (KIR) on the
surface of immune cells, specifically with natural killer (NK)
cells and natural killer-T (NKT) cells.
