Tazarotene Gel vs. Calcipotriol Ointment in Psoriasis

Title: Comparison of tazarotene 0.1% gel plus petrolatum once daily versus calcipotriol 0.005% ointment twice daily in the treatment of plaque psoriasis.
: Tzung TY, et al.
Publication: Acta Derm Venereol. 2005;85(3):236-9.

The authors wanted to compare the effectiveness of psoriasis treatment using tazarotene and calcipotriol.

They enrolled 19 patients with plaque psoriasis. These patients were each given once-daily tazarotene 0.1% gel plus petrolatum (petroleum jelly) and twice-daily calcipotriol 0.005% ointment. Each patient was told to treat some lesion with the tazarotene and others with calcipotriol for 12 weeks. In the study, a total of 44 lesion pairs were compared.

The results:

Week 2 to 8 Calcipotriol has significantly greater effect in reducing erythema (redness of the skin) than tazarotene-petrolatum.
Week 12 (end of treatment) Same efficacy of tazarotene-petrolatum and calcipotriol
Week 16 (4 weeks after end of treatment) Tazarotene-petrolatum had better effect in psoriasis maintenance.

Skin irritation was found only in the tazarotene-petrolatum treatment.

The authors concluded that the once-daily tazarotene 0.1% plus petroleum jelly was as effective as the twice-daily calcipotriol 0.005% ointment for treating psoriasis plaques, but had better maintenance effect after the treatment period was over.

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