Tazarotene for Plaque Psoriasis

Title: Topical tazarotene: a review of its use in the treatment of plaque psoriasis.
: Dando TM and Wellington K
Publication: Am J Clin Dermatol. 2005;6(4):255-72.

Tazarotene or Tazorac is a topica retinoid (derivative of vitamin A) used to treat plaque psoriasis. When used by itself, topical tazarotene is effective at controlling signs and symptoms of plaque psoriasis, and had lower frequency of relapse as compared to fluocinonide cream.

The most common side effects associated with tazarotene are:

  • Itching
  • Burning
  • Erythema or redness

Combination therapy of tazarotene and topical corticosteroid generally result in better efficacy than tazarootene alone, reduce irritation side effects, decrease the risk of post-treatment flare-ups seen in corticosteroid alone, and decrease the degree of skin atrophy or wasting associated with topical corticosteroid.

The combination of tazarotene and ultraviolet light therapy also seems to be promising.

The authors concluded that using tazarotene either by itself or in combination with other therapies are useful treatment options for patients with plaque psoriasis.

Editor’s Note: fluocinonide cream is a topica steroid that reduces or inhibits inflammation, redness, and swelling. It is used to treat a number of conditions, such as allergic reactions, eczema, and psoriasis.

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